I'll have a review for this up in the near future.
Tips for a noob: Be patient.
When you are making your character think ahead as to the kind of character you want to be and consider carefully what sorts of abilities and skills will be useful to you to survive. Don't shortchange personality and dialog areas. Some perks are better than others. You don't have to take or do anything you don't want.
The gunplay is better like people have said... I don't think it's Destiny caliber quite but it's a lot better.... so you can play it like that and you have VATS in your backpocket. I use both. It's nice to have two viable options at all times.
FPS trappings notwithstanding, this is an RPG as well so come in with some of your RPG gaming mindset in play.
"Sneak critical." <- This is how I live and die in these games.
When you are making your character think ahead as to the kind of character you want to be and consider carefully what sorts of abilities and skills will be useful to you to survive.
^Absolutely this. There is no level cap so this one is bit more forgiving but I had a "brain fart" and forgot how the perk trees worked and really kind of shortchanged myself in a few areas.
I would recommend looking at the perks before hand and getting a feel for it. One thing to remember is you don't need the skill above it to use a skill below it. For instance let's say you want the level 8 strength perk. You'll need 8 points into strength to unlock it but after that you can skip right to it. It is not necessary to have the level 1-7 perks you can skip all around as long as the requirements are met. To level some perks up higher is typically locked behind reaching a certain character level though to prevent you from being too overpowered.
For instance Rifleman gives you 20% bonus to damage using non-automatic rifles, then you can level it to 40%, 60%, 80% but the additional percentages may require a higher character level than you are at the time so you'll need to go back to it.
I always recommend leveling up your lockpicking and hacker skills since both can get you out of a bind at times. Beyond that it will depend on what style you want to play. Whether you prefers pistols, rifles, or unarmed. Whether you want to be more stealthy or like to go out guns blazing. As Q said don't shortchange dialog and personality perks either because they open up a lot of options if you wish to avoid conflict in certain situations.
Game is awesome for sure, though I do wish it had more of the good vs bad choices of Fallout 3 and NV. Other than that though I've been having a blast with it. Very easy to sink several hours into it without realizing.
For as great as the game is, I've spent more time working on settlements than doing missions. I'm currently in the process of transitioning away from Sanctuary into the Castle. Have established a few supply lines from my previous bigger settlements to the Castle so that I can make use of their resources. Going to turn the Castle into a nice little city/base of operations.
When I go out and do missions though, I'm rocking a sweet stealth and range build. I've got the Deliverer for my main up close stealth weapon and a sweet sniper for my ranged sneak attacks. Perks I've focused on when possible have been Gunslinger, Ninja, Sneak, Action Boy, and Bloody Mess.
Have been able to clean out areas without ever being seen or shot at, basically one shotting most enemies.
But seriously, the settlements are awesome. I wish there were more options and a better way to build stuff (plus not being so strict about where you can place stuff), but as is I'm just enjoying building a settlement and rocking a little farm.
If anyone is curious how things are going on Fallout 2, I'm at level 7 or 8(the completion of the quest that gave 20K xp was very helpful in that regard and in getting the power armor early on). Currently in some city that starts with a K, grinding away on the guide I printed out.